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The exercise is:

a) Use 'Round to -∞' to round <[101011101]>2 to 5 Digits.

But i'm confused how to interprete <[101011101]>2. Is it the Radix-2 Number 349 or the B-Complement Number -163 or is it a fixpoint or floating point number?

The exercise says radix-2 number. Since it says "to 5 digits" and not "to 5 digits after the point" it does not matter whether or not it is a fixpoint number (note that radix numbers we used up until here are also just fixpoint numbers with their point right of the LSB).